



Understanding the Science of Post-Treatment Reactions
Mechanical Stimulation After PEPTAXEL™ treatment, spicules penetrate the skin, causing mechanical stimulation. Observed Immune Response After Spicule Treatment The mechanical stimulation may trigger an immune response in the skin — as observed in studies of spicule penetration. Zhang, S., Ou, H., Liu, C., Zhang, Y., Mitragotri, S., Wang, D., & Chen, M. (2017) Skin delivery of hydrophilic biomacromolecules using marine sponge spicules. Mol. Pharmaceutics “After the treatment,



