Understanding the Science of Post-Treatment Reactions

Mechanical Stimulation

After PEPTAXEL™ treatment, spicules penetrate the skin, causing mechanical stimulation.

Observed Immune Response After Spicule Treatment

The mechanical stimulation may trigger an immune response in the skin — as observed in studies of spicule penetration.

Zhang, S., Ou, H., Liu, C., Zhang, Y., Mitragotri, S., Wang, D., & Chen, M. (2017) Skin delivery of hydrophilic biomacromolecules using marine sponge spicules. Mol. Pharmaceutics

“After the treatment, immune cells infiltration, either leukocyte or granulocyte, in the upper dermis were observed.”

This indicates that a transient acute immune response can be activated as the skin reacts to spicule penetration.

Understanding Downtime

Zhang, S., Ou, H., Liu, C., Zhang, Y., Mitragotri, S., Wang, D., & Chen, M. (2017) Skin delivery of hydrophilic biomacromolecules using marine sponge spicules. Mol. Pharmaceutics

Activation of immune cells signals that the skin has begun its natural recovery process.

As a result, temporary itching may occur — this is a normal physiological reaction as the skin responds to external stimuli.

*Responses may differ according to individual skin type.

Post-Treatment Care

When the skin activates its natural immune response, mild itching and other temporary discomfort may occur.

In this phase, proper post-treatment care is crucial:

• Relieve discomfort and support recovery: Helps reduce itching, accelerates the skin’s natural healing, and reinforces the skin barrier to protect against further irritation or imbalance.

• Optimize treatment outcomes: Even when the procedure is successful, proper post-treatment care is crucial for accelerated recovery and optimal results.

Key Benefits of Optimal Post-Treatment Care:

• Supports regulation of immune and inflammatory reactions

• Alleviates discomfort and provides intensive soothing

• Reinforces the skin barrier