Purpose: The purpose of this study is to compare and analyze treatment approaches for skin texture improvement, focusing on downtime, invasiveness, and clinical outcomes. Before Products PEPTAXEL ™ Intensive + Brightening (1:1 mix, half used) Glutagen Skin booster applied (half) RFMN PDRN + Hyaluronic acid injected via RFMN device (depths 0.3 mm &1.0 mm) 1cc of PLLA-based skin booster applied topically Preparation Lidocaine applied 10 minutes Lidocaine applied 30 minutes D

Mechanical Stimulation After PEPTAXEL™ treatment, spicules penetrate the skin, causing mechanical stimulation. Observed Immune Response After Spicule Treatment The mechanical stimulation may trigger an immune response in the skin — as observed in studies of spicule penetration. Zhang, S., Ou, H., Liu, C., Zhang, Y., Mitragotri, S., Wang, D., & Chen, M. (2017) Skin delivery of hydrophilic biomacromolecules using marine sponge spicules. Mol. Pharmaceutics “After the treatment,

A multilayer treatment is a procedural approach that targets multiple skin layers, using different technologies optimized for each depth. Why a Multilayer Approach Is Needed? Each treatment primarily targets a single skin layer, and its effects vary by treatment type. Skin concerns are often multi-factorial, requiring a targeted strategy across all layers to enable synergistic improvements. By combining treatments across layers, multilayer approaches enhance both structura